The second edition of Molecular Conformations presents the latest science in the molecular biology of protein folding. A new section contains the latest developments in establishing the mechanisms that control protein folding and – when things go wrong – protein degradation. While the new section is more scientifically involved that the original sections, it has been written in a way that puts the emphasis on general concepts.
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- Genetic origins of amino acids
- Constituents and organisation of DNA
- Folding of DNA
- The codon structure of DNA
- Gene structure
- Transcription and translation
- Transcription
- Translation
- Amino acid geometries and protein folding
- Amino acid structure and bond flexibility
- Principles of protein folding
- Proteostasis, aggregation and degradation
- Proteostasis – overview
- Aggregation
- Nonsense Mediated Decay
- Structure-function relationship of proteins
- Relevance of pH and isoelectric point to proteins
- Surface electrostatic potential
- Affinity and specificity
- Allosteric activation
- Conformational change via epigenetics
- DNA methylation
- Definition of PTMs
- Bromodomains
- Chromodomains
- Domains that bind phosphorylated serines
- Summary