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Introduction to Cancer Biology is a short primer on how cancers develop and grow.
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About the book
Introduction to Cancer Biology is a short primer on how cancers develop and grow. The aim of this book is to provide a gentle exploration of the fundamental concepts in a easy-to-understand format, using examples and key figures for illustration. It is written in a style to help the reader understand the six basic principles that inform our current understanding of cancer, at the molecular, cellular and physiological level. The text can be used either as a first step towards a deeper understanding of the mechanisms of cancer progression or it can be used as a quick revision guide. It would be suitable for anyone, with or without a background in biology.
1. How cancer arises
1.1 Defining cancer
1.2 Cancer is clonal in origin
1.3 Insights into cancer
1.4 Causes of cancer (aetiology of cancer)
1.4.1 Lifestyle and Environment
1.5 Identification and histopathology of cancers
1.6 The 6 hallmarks of cancer
2. Immortality: Continuous cell division
3. Sustained growth signals (oncogenes)
4. Bypass anti-growth signals (Tumour Suppressor Genes)
5. Avoidance of cell death (apoptosis)
5.1 When does apoptosis occur?
5.2 What triggers apoptosis?
5.3 How does apoptosis occur?
6. Ensuring blood vessel growth (angiogenesis)
7. Spread to other sites (metastasis)
7.1 What are the stages of metastasis?
7.2 Key molecules involved in metastasis
8. Summary and some thoughts for the future
About the Author
Dr. Momna V Hejmadi
Dept. Biology & Biochemistry
University of Bath
BATH BA2 7AY
Tel: ++44(0)1225 383129
Fax: ++44(0)1225 386779
Dr. Hejmadi completed her PhD in radiation oncology, studying the biochemical basis of thermotolerance in murine tumours in vivo. Her postdoctoral research on the anti-tumour effects of novel bioreductive drugs in radio and chemotherapy in murine tumours, has led to the drug currently undergoing Phase II clinical trials. Currently, her research interests are in hypoxia signalling pathways in neuronal and cancer models in vitro. She has been teaching cancer biology to undergraduate students at Bath for the past 10 years and has won several awards for her teaching. She has created novel interactive Flash e-resources on this topic, which will soon be part of a UK HEA Open Educational Resources database.
Select research publications
1. Wirrig C, Wilbrey A, Tang TT and Hejmadi MV (2010) Nornicotine-based glycation attenuates β-amyloid aggregation and protects SHSY-5Y neuroblastoma cells (manuscript under preparation – to be submitted to J. Neurochemistry)
2. W Wu, S Crennell, M Danson, D Hough, MV Hejmadi (2010) A novel photolyase from a haloarchaeon, Haloferax volcanii, enhances survival against uv-induced DNA damage (manuscript under preparation – to be submitted to J. Molecular Biology)
3. M Batisson, N Strazielle, M Hejmadi, D Thomas,1 J F Ghersi-Egea, J Etienne, F Vandenesch, G Lina. (2006) Toxic shock syndrome toxin1 challenges neuroprotective functions of the choroidal epithelium and induces neurotoxicity. J. Infectious Diseases Aug 1;194(3):341-9.
4. MV Hejmadi, F Dajas-Bailador, SM Barns, B Jones and S Wonnacott (2003) Neuroprotection by nicotine against hypoxia-induced apoptosis in cortical cultures involves activation of multiple nicotinic acetylcholine receptor subtypes Molecular and Cellular Neuroscience 24 (3):779-86.
5. MV Hejmadi, NS Delany, S Jagannathan, GCColes & AJ Wolstenholme (2000) L-Glutamate binding sites of parasitic nematodes: an association with ivermectin resistance? Parasitology (120)535 – 545.
6. OP Friery, MV Hejmadi and SR McKeown (1997) DNA damage induced in T50/80 tumour cells following exposure to the bioreductive drug tirapazamine in combination with a single dose of radiation (12Gy). Biochemical Society Transactions, 25, 135S (30% contribution)
7. MV Hejmadi, SR McKeown, OP Friery, IA McIntyre, LH Patterson and DG Hirst (1996) DNA damage following combination of radiation with bioreductive drug AQ4N: possible selective toxicity to oxic & hypoxic tumour cells Br J Cancer, 73, 499-505
8. SR McKeown, OP Friery, IA McIntyre, MV Hejmadi, LH Patterson and DG Hirst (1996) Evidence for therapeutic gain when AQ4N or tirapazamine is combined with radiation British J. Cancer, S39 - S42
9. OP Friery, MV Hejmadi, IA McIntyre, JJA McAleer LH Patterson and SR McKeown (1996) Interaction of the novel drug AQ4N with radiation in BDF mice implanted with the T50/80 tumour Irish J.Med.Sci, 165,4: 310.
10. SR McKeown, MV Hejmadi, IA McIntyre, JJ McAleer, LH Patterson (1995) AQ4N showing bioreductive potential & positive interaction with radiation in vivo. Br J Cancer. 1995 Jul;72(1):76-81. (50% contribution)
11. Sharma M, Srinivasan VT, Singh BB (1993) Longitudinal (T1) and transverse (T2) relaxation times of tissue water protons in mouse developing sarcoma 180-A: effect of hyperthermia. Int J Hyperthermia. 1993 Nov-Dec;9 (6):811-9.
1. M V Hejmadi (2007) Improving the effectiveness and efficiency of teaching large classes: Development and evaluation of a novel e-resource in cancer biology. Bioscience Education Electronic Journal Vol 9-2 (http://www.bioscience.heacademy.ac.uk/journal/vol9/beej-9-2.htm)
2. MV Hejmadi (2008) Mentoring scientific minds through group research projects http://www.heacademy.ac.uk/TeachingGuides
3. K. Bullock, Gould G, Hejmadi MV, Lock G (2009) Work Placement Experience: Should I Stay or Should I Go? Higher Education Reseach Development 28 (5), pp. 481-494.
4. Lock, G., Bullock, K., Gould, V., Hejmadi, M.V, (2009). Exploring the Industrial-Placement Experience for Mechanical Engineering Undergraduates. Engineering Education: Journal of the Higher Education Academy, Engineering Subject Centre (4) (1), pp. 42-51.
5. M V Hejmadi (2009) How effective is peer assessment and feedback? An evaluation across diverse teaching activities (Science Learning Teaching Conference, June 16-17, 2009 http://www.bioscience.heacademy.ac.uk/ftp/events/sltc09/presentations/o16hejmadi.pdf )
6. M V Hejmadi (2009) Laboratory practicals: Strategies to enhance student learning (Science Learning Teaching Conference, June 16-17, 2009, http://www.bioscience.heacademy.ac.uk/ftp/events/sltc09/posters/p5hejmadi.pdf )
7. M V Hejmadi (2010) Evaluating a Cancer Biology learning package for OER. OER10 Conference, March 22, 2010. http://www.ucel.ac.uk/oer10/programme_day1.html
- Mary Tasker Award for Excellence in Teaching 2002
- Innovations in Learning and Teaching Award 2008
- Finalists UK HEA Ed Wood Teaching Awards 2009
- Nominated Times Higher Education ‘Innovations in Teaching’ award 2009
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Elizabeth C. Peterson ★★★★★
Clear and concise in its form. Highly recommended for nurses like me and other medical-related courses, and to those who want to enhance their knowledge about the illness.