Download for FREE in 4 easy steps...
This is a Premium eBook - get it free for 30 days
You can also read this in Bookboon.com Premium
In many types of biochemical and pharmaceutical industries fluid bed granulation in the form of agglomeration and coating processes are essential unit operations in the production of solid products.
300+ Business books exclusively in our Premium eReader
- No adverts
- Advanced features
- Personal library
Users who viewed this item also viewed
Hydrodynamic Modelling and Granular Dynamics
Fluid Bed Particle Processing
Pressure Driven Membrane Processes
Electrically Driven Membrane Processes
Modelling Batch Systems Using Population Balances
Fundamentals of Reaction Engineering
Micro- and Nano-Transport of Biomolecules
About the book
In many types of biochemical and pharmaceutical industries fluid bed granulation in the form of agglomeration and coating processes are essential unit operations in the production of solid products. In order to fully understand the underlying mechanisms behind the numerous phenomena taking place during granulation, it is necessary to study the particle-level phenomena. This is the topic for the present text where relevant models and theory are presented. Thus, you will get an in-depth analysis of the advanced particle-level principles and theory within this important field on a bachelor or master-of-science level.
The present text concerns the micro-level (particle-level) perspective on the different stages of the granulation process. A range of the newest and advanced quantitative models is presented hereby introducing recent advances in wetting and nucleation modelling, and theory describing granule growth behaviour. The different bonding mechanisms and the strength of liquid bonded particles are emphasised and recent advances in simulation of wet granule breakage is reviewed. Further, some of the more advanced coalescence models are introduced with primary focus on class I models accounting for coalescence of non-deformable as well as deformable granules.
The text is aimed at undergraduate university or engineering-school students working in the field chemical and biochemical engineering as well as particle technology. Newly graduated as well as experienced engineers may also find relevant new information as emphasis is put on the newest scientific discoveries and proposals presented in the last few years of scientific publications. It is the hope that the present text will provide a complete and up-to-date image of how far modern granulation theory has come, and also further provide the reader with qualitative rules of thumb that may be essential when working with granulation processes. The comprehensive literature list may also hopefully be an inspiration for further reading.
I alone am responsible for any misprints or errors and I will be grateful to receive any critics and/or suggestions for further improvements.
Copenhagen, September 2006
Peter Dybdahl Hede
1. Fluid bed agglomeration at particle level
1.1 Mechanisms involved in the growth rate of granules
1.2 Wetting and nucleation
1.3 Granule growth behaviour and kinetics
1.3.1 Mechanical properties of liquid-bound granules
126.96.36.199 Interparticle forces
188.8.131.52 Static strength – capillary and surface tension forces
184.108.40.206 Dynamic strength - viscous forces
220.127.116.11 Breakage and attrition of wet granules
18.104.22.168 Wet granule strength summary
1.3.2 Granule growth modelling – Class I and Class II models
22.214.171.124 Class I models: Coalescence of non-deformable granules
126.96.36.199 Class I models: Coalescence of deformable granules
1.3.3 Granule growth regimes
Table of symbols
The embed frame is free to use for private persons, universities and schools. It is not allowed to be used by any company for commercial purposes unless it is for media coverage. You may not modify, build upon, or block any portion or functionality of the embed frame, including but not limited to links back to the bookboon.com website.
The Embed frame may not be used as part of a commercial business offering. The embed frame is intended for private people who want to share eBooks on their website or blog, professors or teaching professionals who want to make an eBook available directly on their page, and media, journalists or bloggers who wants to discuss a given eBook
If you are in doubt about whether you can implement the embed frame, you are welcome to contact Thomas Buus Madsen on firstname.lastname@example.org and seek permission.