Molecular Conformations

The three-dimensional shape of a protein determines its function. The shape of proteins can change by small or large amounts; another term for shape is conformation.

Molecular Conformations introduces the fundamental physical and biochemical concepts that determine the conformation of a protein. The book starts by describing how DNA is converted into proteins and then continues with those factors that influence conformational change in a protein.

The book is essential reading for anyone who wants to understand how proteins execute their biochemical functions.

1. Genetic origins of amino acids
1.1 Constituents and organisation of DNA
1.2 Folding of DNA
1.3 The codon structure of DNA
1.4 Gene structure

2. Transcription and translation
2.1 Transcription
2.2 Translation
2.2.1 Transfer RNA
2.2.2 Protein formation by ribosomes
2.2.3 Open reading frames of mRNA

3. Amino acid geometries and protein folding
3.1 Amino acid structure and bond flexibility
3.2 Principles of protein folding
3.2.1 Formation of secondary-structure elements
3.2.2 Causes and consequences of misfolding
3.2.3 Mechanisms of protein folding

4. Structure-function relationship of proteins
4.1 Relevance of pH and isoelectric point to proteins
4.2 Surface electrostatic potential
4.3 Affinity and specificity
4.4 Allosteric activation

5. Conformational change via epigenetics
5.1 DNA methylation
5.2 Definition of PTMs
5.3 Bromodomains
5.4 Chromodomains
5.5 Domains that bind phosphorylated serines

6. Summary